Drug interactions
Hydrochlorothiazide-lisinopril + Minoxidil
Severity: Moderate
Hydrochlorothiazide-lisinopril and Minoxidil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Minoxidil is a potent vasodilator, and combining it with an ACE inhibitor and thiazide produces additive blood pressure lowering. Thiazide or loop diuretics are commonly given with minoxidil to counter fluid retention, so the combination is often intentional but can cause excessive hypotension.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Minoxidil belongs to Cardiovascular.
Why it happens
Additive vasodilation and volume reduction lower blood pressure.
What to do
Monitor blood pressure, heart rate and fluid status, and adjust doses accordingly, especially at initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Minoxidil
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Minoxidil?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Minoxidil is a potent vasodilator, and combining it with an ACE inhibitor and thiazide produces additive blood pressure lowering. Thiazide or loop diuretics are commonly given with minoxidil to counter fluid retention, so the combination is often intentional but can cause excessive hypotension.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Minoxidil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and fluid status, and adjust doses accordingly, especially at initiation.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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