Drug interactions
Hydrochlorothiazide-lisinopril + Ofloxacin
Severity: Minor
Hydrochlorothiazide-lisinopril and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin is renally eliminated and thiazides may marginally reduce its tubular secretion. Clinically significant changes are not established, though both drugs can be relevant to electrolyte disturbances and QT effects in at-risk patients.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion; thiazide hypokalemia may add to QT risk.
What to do
No dose change is usually needed; check potassium and magnesium in patients with QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Ofloxacin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ofloxacin is renally eliminated and thiazides may marginally reduce its tubular secretion. Clinically significant changes are not established, though both drugs can be relevant to electrolyte disturbances and QT effects in at-risk patients.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; check potassium and magnesium in patients with QT risk factors.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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