Drug interactions
Hydrochlorothiazide-lisinopril + Potassium chloride
Severity: Moderate
Hydrochlorothiazide-lisinopril and Potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium chloride with lisinopril can cause hyperkalemia because ACE inhibitors reduce potassium excretion. Hydrochlorothiazide opposes this, but the net effect varies, especially with renal impairment or diabetes.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Potassium chloride belongs to Gastrointestinal Tract.
Why it happens
ACE inhibition reduces aldosterone-mediated potassium excretion, while thiazide causes potassium loss.
What to do
Check serum potassium and creatinine within the first weeks of therapy and periodically thereafter, and adjust or stop the supplement if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Potassium chloride
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Potassium chloride?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium chloride with lisinopril can cause hyperkalemia because ACE inhibitors reduce potassium excretion. Hydrochlorothiazide opposes this, but the net effect varies, especially with renal impairment or diabetes.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine within the first weeks of therapy and periodically thereafter, and adjust or stop the supplement if potassium rises.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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