Drug interactions
Hydrochlorothiazide-lisinopril + Quinine
Severity: Moderate
Hydrochlorothiazide-lisinopril and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-induced hypokalemia or hypomagnesemia may add to the QT-prolonging potential of quinine. A pharmacokinetic effect on quinine clearance is theoretical and unlikely to be important.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Electrolyte disturbance from thiazide potentiates quinine QT prolongation; theoretical competition for renal secretion.
What to do
Check and correct potassium and magnesium before and during quinine therapy, and consider ECG monitoring in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Quinine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-induced hypokalemia or hypomagnesemia may add to the QT-prolonging potential of quinine. A pharmacokinetic effect on quinine clearance is theoretical and unlikely to be important.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during quinine therapy, and consider ECG monitoring in patients with other QT risk factors.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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