Drug interactions
Hydrochlorothiazide-lisinopril + Salmeterol
Severity: Moderate
Hydrochlorothiazide-lisinopril and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol and hydrochlorothiazide can both lower serum potassium, and the combination may cause clinically significant hypokalemia and ECG changes, mainly at higher doses or in susceptible patients.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Beta-2 agonist stimulation drives potassium into cells while the thiazide increases renal potassium loss.
What to do
Monitor serum potassium in patients with severe asthma or COPD, or those at risk of arrhythmia, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Salmeterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol and hydrochlorothiazide can both lower serum potassium, and the combination may cause clinically significant hypokalemia and ECG changes, mainly at higher doses or in susceptible patients.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with severe asthma or COPD, or those at risk of arrhythmia, and replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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