Drug interactions
Hydrochlorothiazide-lisinopril + Timolol
Severity: Minor
Hydrochlorothiazide-lisinopril and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers such as timolol can slightly raise serum potassium, while hydrochlorothiazide lowers it, so the net effect is unpredictable and usually small. Timolol also adds to the blood pressure lowering of the antihypertensive combination, which is often intended but can cause excessive hypotension or bradycardia.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Opposing potassium effects (reduced cellular uptake with beta-blockade versus thiazide renal loss) plus additive antihypertensive pharmacodynamics.
What to do
Check blood pressure, heart rate and serum potassium after starting or changing doses. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Timolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers such as timolol can slightly raise serum potassium, while hydrochlorothiazide lowers it, so the net effect is unpredictable and usually small. Timolol also adds to the blood pressure lowering of the antihypertensive combination, which is often intended but can cause excessive hypotension or bradycardia.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure, heart rate and serum potassium after starting or changing doses. No dose change is usually needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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