Drug interactions
Hydrochlorothiazide-lisinopril + Tretinoin
Severity: Minor
Hydrochlorothiazide-lisinopril and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can cause photosensitivity, and tretinoin makes skin more sensitive to UV light. The combination may increase sunburn-like reactions on exposed skin. Oral tretinoin also has its own systemic toxicity.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects; no pharmacokinetic interaction is established.
What to do
Advise sunscreen, protective clothing and sun avoidance. Reduce tretinoin use if phototoxic reactions develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Tretinoin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can cause photosensitivity, and tretinoin makes skin more sensitive to UV light. The combination may increase sunburn-like reactions on exposed skin. Oral tretinoin also has its own systemic toxicity.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise sunscreen, protective clothing and sun avoidance. Reduce tretinoin use if phototoxic reactions develop.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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