Drug interactions
Hydrochlorothiazide-lisinopril + Triamterene
Severity: Major
Hydrochlorothiazide-lisinopril and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a potassium-sparing diuretic, and with lisinopril it can cause clinically significant hyperkalemia. Hydrochlorothiazide partly counters this, but the risk is higher in renal impairment, diabetes and older patients.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene blocks the epithelial sodium channel and lisinopril lowers aldosterone, both decreasing renal potassium excretion.
What to do
Check serum potassium and renal function within the first week and periodically afterward; avoid in significant renal impairment and stop triamterene if hyperkalemia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Triamterene?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triamterene is a potassium-sparing diuretic, and with lisinopril it can cause clinically significant hyperkalemia. Hydrochlorothiazide partly counters this, but the risk is higher in renal impairment, diabetes and older patients.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function within the first week and periodically afterward; avoid in significant renal impairment and stop triamterene if hyperkalemia develops.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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