Drug interactions
Hydrochlorothiazide-lisinopril + Valganciclovir
Severity: Moderate
Hydrochlorothiazide-lisinopril and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganciclovir, the active form of valganciclovir, is cleared by the kidney, and diuretic-related volume depletion or reduced renal function may raise its levels. This can increase hematologic toxicity such as neutropenia.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Valganciclovir belongs to Anti Virals.
Why it happens
Reduced renal clearance of ganciclovir through volume depletion and possible competition for tubular secretion.
What to do
Monitor renal function and blood counts, and adjust valganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Valganciclovir?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganciclovir, the active form of valganciclovir, is cleared by the kidney, and diuretic-related volume depletion or reduced renal function may raise its levels. This can increase hematologic toxicity such as neutropenia.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts, and adjust valganciclovir dose to creatinine clearance.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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