Drug interactions
Hydrochlorothiazide-lisinopril + Valsartan
Severity: Major
Hydrochlorothiazide-lisinopril and Valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade, which increases the risk of hypotension, hyperkalemia and acute kidney injury without clear added cardiovascular benefit. The thiazide partly offsets potassium retention but does not prevent renal or hyperkalemic complications.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Dual blockade of the renin-angiotensin-aldosterone system with additive reductions in aldosterone and glomerular filtration pressure.
What to do
Avoid the combination in general, particularly in diabetic nephropathy. If used, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Valsartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ACE inhibitor with an angiotensin receptor blocker gives dual renin-angiotensin system blockade, which increases the risk of hypotension, hyperkalemia and acute kidney injury without clear added cardiovascular benefit. The thiazide partly offsets potassium retention but does not prevent renal or hyperkalemic complications.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in general, particularly in diabetic nephropathy. If used, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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