Drug interactions
Hydrochlorothiazide-losartan + Imatinib
Severity: Minor
Hydrochlorothiazide-losartan and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2C9 and CYP3A4 and could reduce activation of losartan to E-3174, altering its effect. The clinical significance has not been established.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Imatinib belongs to Oncology.
Why it happens
Possible inhibition of CYP2C9 and CYP3A4-mediated conversion of losartan to its active metabolite.
What to do
Monitor blood pressure when imatinib is started or stopped and adjust the losartan dose if the response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Imatinib?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2C9 and CYP3A4 and could reduce activation of losartan to E-3174, altering its effect. The clinical significance has not been established.
How serious is the interaction between Hydrochlorothiazide-losartan and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when imatinib is started or stopped and adjust the losartan dose if the response changes.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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