Drug interactions
Hydrochlorothiazide-losartan + Isavuconazonium
Severity: Minor
Hydrochlorothiazide-losartan and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and a substrate of CYP3A4, but losartan is only a weak CYP3A4 inhibitor, so any increase in isavuconazole exposure is likely small. The more relevant effect would be isavuconazole raising losartan exposure, which is of modest clinical importance.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Isavuconazonium belongs to Anti Fungals.
Why it happens
Losartan is at most a weak CYP3A4 inhibitor, and the effect on isavuconazole exposure has not been clearly established.
What to do
No routine adjustment is needed. Monitor blood pressure and for adverse effects if either drug is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Isavuconazonium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Isavuconazonium?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a moderate CYP3A4 inhibitor and a substrate of CYP3A4, but losartan is only a weak CYP3A4 inhibitor, so any increase in isavuconazole exposure is likely small. The more relevant effect would be isavuconazole raising losartan exposure, which is of modest clinical importance.
How serious is the interaction between Hydrochlorothiazide-losartan and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood pressure and for adverse effects if either drug is started or stopped.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
