Drug interactions
Hydrochlorothiazide-losartan + Mesalamine
Severity: Minor
Hydrochlorothiazide-losartan and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can affect the kidney, and thiazides may compete for tubular secretion of mesalamine metabolites. Clinically relevant effects are unlikely, though mesalamine can rarely cause nephrotoxicity.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Possible competition for renal tubular anionic secretion.
What to do
No adjustment is needed; monitor renal function periodically, especially with dehydration or concurrent losartan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Mesalamine
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Mesalamine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can affect the kidney, and thiazides may compete for tubular secretion of mesalamine metabolites. Clinically relevant effects are unlikely, though mesalamine can rarely cause nephrotoxicity.
How serious is the interaction between Hydrochlorothiazide-losartan and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor renal function periodically, especially with dehydration or concurrent losartan.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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