Drug interactions
Hydrochlorothiazide-losartan + Methoxsalen
Severity: Moderate
Hydrochlorothiazide-losartan and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a recognized photosensitizer, and methoxsalen is used to induce photosensitivity for phototherapy. Together they may increase the risk of phototoxic reactions such as severe sunburn.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects of thiazide and psoralen on skin exposed to ultraviolet light.
What to do
Advise strict photoprotection and avoidance of sun exposure. Consider lowering UVA dosing and monitor the skin closely during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Methoxsalen?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a recognized photosensitizer, and methoxsalen is used to induce photosensitivity for phototherapy. Together they may increase the risk of phototoxic reactions such as severe sunburn.
How serious is the interaction between Hydrochlorothiazide-losartan and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict photoprotection and avoidance of sun exposure. Consider lowering UVA dosing and monitor the skin closely during treatment.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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