Drug interactions
Hydrochlorothiazide-losartan + Mifepristone
Severity: Minor
Hydrochlorothiazide-losartan and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may alter losartan metabolism. Because CYP2C9 is the main pathway for activation, the clinical effect is likely small. Mifepristone used for Cushing syndrome may also cause hypokalemia, adding to thiazide-related potassium loss.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone may modestly alter losartan metabolism.
What to do
No routine dose change is needed. Monitor blood pressure and serum potassium, particularly during long-term mifepristone therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Mifepristone?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4 and may alter losartan metabolism. Because CYP2C9 is the main pathway for activation, the clinical effect is likely small. Mifepristone used for Cushing syndrome may also cause hypokalemia, adding to thiazide-related potassium loss.
How serious is the interaction between Hydrochlorothiazide-losartan and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure and serum potassium, particularly during long-term mifepristone therapy.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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