Drug interactions
Hydrochlorothiazide-losartan + Mitotane
Severity: Moderate
Hydrochlorothiazide-losartan and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and may also induce CYP2C9, which could reduce formation of losartan's active metabolite and reduce its blood pressure effect.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4 (and possibly CYP2C9), increasing losartan metabolism.
What to do
Monitor blood pressure after starting mitotane and increase the antihypertensive dose if control is inadequate; mitotane induction can persist after stopping.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Mitotane?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and may also induce CYP2C9, which could reduce formation of losartan's active metabolite and reduce its blood pressure effect.
How serious is the interaction between Hydrochlorothiazide-losartan and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting mitotane and increase the antihypertensive dose if control is inadequate; mitotane induction can persist after stopping.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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