Drug interactions
Hydrochlorothiazide-losartan + Nadolol
Severity: Minor
Hydrochlorothiazide-losartan and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol combined with losartan and hydrochlorothiazide produces additive blood pressure lowering, which is often intended but may cause excessive hypotension or bradycardia. Beta-blockers can also modestly raise potassium, while the thiazide may lower it.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects from different mechanisms, with minor beta-blocker effects on potassium shift.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses. Check serum potassium periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Nadolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nadolol combined with losartan and hydrochlorothiazide produces additive blood pressure lowering, which is often intended but may cause excessive hypotension or bradycardia. Beta-blockers can also modestly raise potassium, while the thiazide may lower it.
How serious is the interaction between Hydrochlorothiazide-losartan and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses. Check serum potassium periodically.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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