Drug interactions
Hydrochlorothiazide-losartan + Oliceridine
Severity: Moderate
Hydrochlorothiazide-losartan and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may stimulate antidiuretic hormone release and reduce diuretic response. Oliceridine can also cause hypotension, which may add to the effect of the antihypertensive combination.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Opioid-induced ADH release reduces diuresis; additive hypotension through opioid vasodilation and histamine-independent central effects.
What to do
Monitor blood pressure, fluid status and urine output during oliceridine therapy and adjust the diuretic or antihypertensive as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Oliceridine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids may stimulate antidiuretic hormone release and reduce diuretic response. Oliceridine can also cause hypotension, which may add to the effect of the antihypertensive combination.
How serious is the interaction between Hydrochlorothiazide-losartan and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and urine output during oliceridine therapy and adjust the diuretic or antihypertensive as required.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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