Drug interactions
Hydrochlorothiazide-losartan + Piperacillin
Severity: Minor
Hydrochlorothiazide-losartan and Piperacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are renally secreted and thiazides might modestly reduce piperacillin clearance. Piperacillin can also lower potassium, adding to diuretic-related hypokalemia.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Piperacillin belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion; additive potassium loss.
What to do
Monitor serum potassium and renal function during piperacillin therapy; no dose change is routinely required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Piperacillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are renally secreted and thiazides might modestly reduce piperacillin clearance. Piperacillin can also lower potassium, adding to diuretic-related hypokalemia.
How serious is the interaction between Hydrochlorothiazide-losartan and Piperacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during piperacillin therapy; no dose change is routinely required.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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