Drug interactions
Hydrochlorothiazide-losartan + Probenecid
Severity: Moderate
Hydrochlorothiazide-losartan and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide reduces uric acid excretion and can raise serum urate, opposing the uricosuric effect of probenecid. Thiazides also compete for renal tubular secretion, and losartan has a mild uricosuric effect.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Thiazide-induced urate retention and competition for organic anion tubular secretion antagonise probenecid.
What to do
Monitor serum uric acid and gout control and adjust probenecid dose as needed. Consider an alternative to the thiazide if urate lowering is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Probenecid?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide reduces uric acid excretion and can raise serum urate, opposing the uricosuric effect of probenecid. Thiazides also compete for renal tubular secretion, and losartan has a mild uricosuric effect.
How serious is the interaction between Hydrochlorothiazide-losartan and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control and adjust probenecid dose as needed. Consider an alternative to the thiazide if urate lowering is inadequate.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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