Drug interactions
Hydrochlorothiazide-losartan + Secobarbital
Severity: Minor
Hydrochlorothiazide-losartan and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates may induce CYP2C9 and lower exposure to losartan and its active metabolite, potentially weakening blood pressure control. Barbiturates can also add to orthostatic hypotension caused by antihypertensives.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Enzyme induction of CYP2C9/CYP3A4 by secobarbital increases losartan metabolism; additive hypotensive effects may also occur.
What to do
Monitor blood pressure when secobarbital is started or stopped and increase the losartan dose if needed. Counsel patients about dizziness on standing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Secobarbital?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates may induce CYP2C9 and lower exposure to losartan and its active metabolite, potentially weakening blood pressure control. Barbiturates can also add to orthostatic hypotension caused by antihypertensives.
How serious is the interaction between Hydrochlorothiazide-losartan and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when secobarbital is started or stopped and increase the losartan dose if needed. Counsel patients about dizziness on standing.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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