Drug interactions
Hydrochlorothiazide-losartan + Voclosporin
Severity: Major
Hydrochlorothiazide-losartan and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause hyperkalemia, hypertension and nephrotoxicity. Combining it with an ARB and a thiazide increases the risk of hyperkalemia and acute reductions in renal function.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor-induced renal vasoconstriction and reduced potassium excretion combine with ARB inhibition of aldosterone and glomerular efferent tone.
What to do
Monitor serum potassium, creatinine and eGFR closely, particularly in the first weeks. Adjust voclosporin dose per label for eGFR decline and review the ARB if hyperkalemia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Voclosporin?
MediHelp rates the interaction as major. Hydrochlorothiazide-losartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can cause hyperkalemia, hypertension and nephrotoxicity. Combining it with an ARB and a thiazide increases the risk of hyperkalemia and acute reductions in renal function.
How serious is the interaction between Hydrochlorothiazide-losartan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and eGFR closely, particularly in the first weeks. Adjust voclosporin dose per label for eGFR decline and review the ARB if hyperkalemia develops.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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