Drug interactions
Hydrochlorothiazide-olmesartan + Sotalol
Severity: Major
Hydrochlorothiazide-olmesartan and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-induced hypokalemia and hypomagnesemia increase the risk of QT prolongation and torsades de pointes with sotalol. Additive hypotension and bradycardia can also occur with the ARB and beta-blocker effects.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Electrolyte depletion from hydrochlorothiazide potentiates sotalol's QT-prolonging action, with additive antihypertensive effects.
What to do
Check and correct potassium and magnesium before and during therapy. Monitor ECG for QT interval, heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Sotalol?
MediHelp rates the interaction as major. Hydrochlorothiazide-olmesartan and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thiazide-induced hypokalemia and hypomagnesemia increase the risk of QT prolongation and torsades de pointes with sotalol. Additive hypotension and bradycardia can also occur with the ARB and beta-blocker effects.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during therapy. Monitor ECG for QT interval, heart rate and blood pressure.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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