Drug interactions
Hydrochlorothiazide-telmisartan + Labetalol
Severity: Moderate
Hydrochlorothiazide-telmisartan and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol adds to the blood pressure lowering effect of telmisartan and hydrochlorothiazide, which can cause hypotension, dizziness or bradycardia. This combination is often used deliberately, but the dose needs careful adjustment in volume-depleted patients.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering through alpha and beta blockade combined with angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate when starting or titrating, and reduce doses if symptomatic hypotension occurs. Check potassium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Labetalol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol adds to the blood pressure lowering effect of telmisartan and hydrochlorothiazide, which can cause hypotension, dizziness or bradycardia. This combination is often used deliberately, but the dose needs careful adjustment in volume-depleted patients.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating, and reduce doses if symptomatic hypotension occurs. Check potassium periodically.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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