Drug interactions
Hydrochlorothiazide-telmisartan + Letermovir
Severity: Moderate
Hydrochlorothiazide-telmisartan and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits hepatic OATP1B1/3 transporters, and telmisartan is a substrate that may reach higher concentrations. Telmisartan could in turn modestly raise letermovir exposure through the same transporters. Clinical significance is likely modest.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Mutual OATP1B1/3 transporter competition and inhibition affecting hepatic uptake.
What to do
Monitor blood pressure and for telmisartan adverse effects such as hypotension and hyperkalemia during letermovir therapy. Adjust the telmisartan dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Letermovir?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits hepatic OATP1B1/3 transporters, and telmisartan is a substrate that may reach higher concentrations. Telmisartan could in turn modestly raise letermovir exposure through the same transporters. Clinical significance is likely modest.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for telmisartan adverse effects such as hypotension and hyperkalemia during letermovir therapy. Adjust the telmisartan dose if needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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