Drug interactions
Hydrochlorothiazide-telmisartan + Lornoxicam
Severity: Major
Hydrochlorothiazide-telmisartan and Lornoxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam combined with an ARB and a thiazide increase the risk of acute kidney injury, especially in elderly or volume-depleted patients. NSAIDs also blunt the antihypertensive effect and can cause fluid retention and hyperkalemia.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces afferent arteriolar dilation, while ARB blocks efferent tone and diuretic lowers volume, reducing glomerular filtration.
What to do
Avoid or limit NSAID use where possible and keep the patient well hydrated. Monitor blood pressure, serum creatinine and potassium after starting and periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Lornoxicam?
MediHelp rates the interaction as major. Hydrochlorothiazide-telmisartan and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as lornoxicam combined with an ARB and a thiazide increase the risk of acute kidney injury, especially in elderly or volume-depleted patients. NSAIDs also blunt the antihypertensive effect and can cause fluid retention and hyperkalemia.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit NSAID use where possible and keep the patient well hydrated. Monitor blood pressure, serum creatinine and potassium after starting and periodically.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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