Drug interactions
Hydrochlorothiazide-telmisartan + Memantine
Severity: Minor
Hydrochlorothiazide-telmisartan and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated mainly by the kidney through tubular secretion, and thiazides could theoretically compete for this pathway. The clinical effect is probably small. Memantine exposure may be altered slightly.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Possible competition for renal tubular cationic secretion; thiazide-induced volume depletion may also reduce renal clearance.
What to do
No dose change is usually needed. Watch for dizziness, confusion or agitation, especially in older patients or those with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Memantine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated mainly by the kidney through tubular secretion, and thiazides could theoretically compete for this pathway. The clinical effect is probably small. Memantine exposure may be altered slightly.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Watch for dizziness, confusion or agitation, especially in older patients or those with reduced renal function.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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