Drug interactions
Hydrochlorothiazide-telmisartan + Pravastatin
Severity: Minor
Hydrochlorothiazide-telmisartan and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan has been suggested to inhibit OATP1B1, which could slightly raise pravastatin exposure. Clinically meaningful myopathy is unlikely.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Pravastatin belongs to Cardiovascular.
Why it happens
Possible inhibition of hepatic OATP1B1 uptake of pravastatin by telmisartan.
What to do
No routine dose adjustment is needed. Advise patients to report unexplained muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Pravastatin
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Pravastatin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telmisartan has been suggested to inhibit OATP1B1, which could slightly raise pravastatin exposure. Clinically meaningful myopathy is unlikely.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Advise patients to report unexplained muscle symptoms.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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