Drug interactions
Hydrochlorothiazide-telmisartan + Revefenacin
Severity: Moderate
Hydrochlorothiazide-telmisartan and Revefenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Revefenacin is converted to an active metabolite that is a substrate of OATP1B1 and OATP1B3. Inhibition of these transporters by telmisartan may increase systemic exposure to the metabolite and anticholinergic effects such as dry mouth, urinary retention and tachycardia.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Revefenacin belongs to Respiratory.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of revefenacin's active metabolite.
What to do
Monitor for anticholinergic adverse effects when combined. Consider an alternative inhaled bronchodilator if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Revefenacin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Revefenacin is converted to an active metabolite that is a substrate of OATP1B1 and OATP1B3. Inhibition of these transporters by telmisartan may increase systemic exposure to the metabolite and anticholinergic effects such as dry mouth, urinary retention and tachycardia.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Revefenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects when combined. Consider an alternative inhaled bronchodilator if effects are troublesome.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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