Drug interactions
Hydrochlorothiazide-telmisartan + Succinylcholine
Severity: Moderate
Hydrochlorothiazide-telmisartan and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can cause a transient rise in serum potassium, particularly in patients with burns, denervation or prolonged immobilisation. Telmisartan reduces potassium excretion, whereas hydrochlorothiazide tends to lower it, so the net effect is unpredictable. Hyperkalemia during anesthesia could lead to arrhythmias.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Succinylcholine depolarisation releases potassium from muscle, adding to angiotensin receptor blocker-related potassium retention, partly offset by thiazide kaliuresis.
What to do
Check serum potassium and renal function before surgery and correct abnormalities. Monitor ECG and potassium during and after succinylcholine administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Succinylcholine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine can cause a transient rise in serum potassium, particularly in patients with burns, denervation or prolonged immobilisation. Telmisartan reduces potassium excretion, whereas hydrochlorothiazide tends to lower it, so the net effect is unpredictable. Hyperkalemia during anesthesia could lead to arrhythmias.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function before surgery and correct abnormalities. Monitor ECG and potassium during and after succinylcholine administration.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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