Drug interactions
Hydrochlorothiazide-telmisartan + Torsemide
Severity: Moderate
Hydrochlorothiazide-telmisartan and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Torsemide is a loop diuretic that adds to the diuretic and hypotensive effect of the combination and increases potassium and magnesium loss. Excess volume depletion may cause hypotension and renal impairment, while telmisartan partly offsets potassium loss.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Sequential nephron blockade by loop and thiazide diuretics produces additive natriuresis and potassium wasting, with volume depletion augmenting the angiotensin receptor blocker effect.
What to do
Monitor electrolytes, creatinine, weight and blood pressure, and reduce diuretic doses if hypotension or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Torsemide
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Torsemide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Torsemide is a loop diuretic that adds to the diuretic and hypotensive effect of the combination and increases potassium and magnesium loss. Excess volume depletion may cause hypotension and renal impairment, while telmisartan partly offsets potassium loss.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure, and reduce diuretic doses if hypotension or volume depletion develops.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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