Drug interactions
Hydrochlorothiazide-valsartan + Labetalol
Severity: Moderate
Hydrochlorothiazide-valsartan and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol adds to the blood pressure lowering effect of valsartan and hydrochlorothiazide, which is often intended but can cause symptomatic hypotension or dizziness. Beta-blockers may also slightly raise potassium, while the thiazide lowers it.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through combined alpha- and beta-adrenergic blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate, and adjust doses if hypotension occurs. Check electrolytes periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-valsartan and Labetalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Labetalol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol adds to the blood pressure lowering effect of valsartan and hydrochlorothiazide, which is often intended but can cause symptomatic hypotension or dizziness. Beta-blockers may also slightly raise potassium, while the thiazide lowers it.
How serious is the interaction between Hydrochlorothiazide-valsartan and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and adjust doses if hypotension occurs. Check electrolytes periodically.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
