Drug interactions
Hydrochlorothiazide-valsartan + Liraglutide
Severity: Moderate
Hydrochlorothiazide-valsartan and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan may slightly enhance glucose lowering, whereas hydrochlorothiazide can raise blood glucose and partly counteract liraglutide. Liraglutide-related nausea, vomiting or diarrhea may also cause volume depletion and kidney injury in patients taking a diuretic and valsartan.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Opposing effects on insulin sensitivity from thiazide and angiotensin receptor blockade, plus additive risk of dehydration-related renal impairment.
What to do
Monitor glycemic control when thiazide therapy is started or changed. Advise adequate hydration and check renal function if gastrointestinal symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Liraglutide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan may slightly enhance glucose lowering, whereas hydrochlorothiazide can raise blood glucose and partly counteract liraglutide. Liraglutide-related nausea, vomiting or diarrhea may also cause volume depletion and kidney injury in patients taking a diuretic and valsartan.
How serious is the interaction between Hydrochlorothiazide-valsartan and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when thiazide therapy is started or changed. Advise adequate hydration and check renal function if gastrointestinal symptoms occur.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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