Drug interactions
Hydrochlorothiazide-valsartan + Lovastatin
Severity: Minor
Hydrochlorothiazide-valsartan and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The proposed rise in valsartan exposure through hepatic uptake inhibition by lovastatin is theoretical and unlikely to matter clinically. No meaningful change in blood pressure control is expected.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Lovastatin belongs to Cardiovascular.
Why it happens
Possible OATP1B1 competition reducing hepatic uptake of valsartan; evidence is largely in vitro.
What to do
No dose adjustment is needed. Routine blood pressure monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Lovastatin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The proposed rise in valsartan exposure through hepatic uptake inhibition by lovastatin is theoretical and unlikely to matter clinically. No meaningful change in blood pressure control is expected.
How serious is the interaction between Hydrochlorothiazide-valsartan and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Routine blood pressure monitoring is sufficient.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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