Drug interactions
Hydrochlorothiazide-valsartan + Lurasidone
Severity: Moderate
Hydrochlorothiazide-valsartan and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension through alpha-1 adrenergic blockade. Combined with an ARB and a thiazide diuretic, blood pressure lowering may be greater than intended, especially on initiation or dose increases, raising the risk of dizziness and falls.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic antagonism by lurasidone and the RAAS blockade and diuresis of valsartan and hydrochlorothiazide.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating lurasidone. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Lurasidone?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension through alpha-1 adrenergic blockade. Combined with an ARB and a thiazide diuretic, blood pressure lowering may be greater than intended, especially on initiation or dose increases, raising the risk of dizziness and falls.
How serious is the interaction between Hydrochlorothiazide-valsartan and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating lurasidone. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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