Drug interactions
Hydrochlorothiazide-valsartan + Metoprolol
Severity: Minor
Hydrochlorothiazide-valsartan and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol is commonly combined with ARBs and thiazides for hypertension, giving additive blood pressure lowering that is usually beneficial but can cause hypotension or bradycardia. Thiazides and beta-blockers may also modestly impair glucose and lipid control.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta-1 blockade, RAAS blockade and diuresis.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses. Check glucose in patients with diabetes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Metoprolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoprolol is commonly combined with ARBs and thiazides for hypertension, giving additive blood pressure lowering that is usually beneficial but can cause hypotension or bradycardia. Thiazides and beta-blockers may also modestly impair glucose and lipid control.
How serious is the interaction between Hydrochlorothiazide-valsartan and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses. Check glucose in patients with diabetes.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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