Drug interactions
Hydrochlorothiazide-valsartan + Succinylcholine
Severity: Moderate
Hydrochlorothiazide-valsartan and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can raise serum potassium acutely, and thiazide-induced electrolyte disturbances may alter this response and neuromuscular blockade. Clinical significance is usually modest but relevant perioperatively.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Succinylcholine depolarization releases potassium, while thiazides cause potassium and magnesium depletion that may prolong or alter neuromuscular blockade.
What to do
Check electrolytes before anesthesia and correct abnormalities. Monitor neuromuscular function and ECG during and after administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Succinylcholine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine can raise serum potassium acutely, and thiazide-induced electrolyte disturbances may alter this response and neuromuscular blockade. Clinical significance is usually modest but relevant perioperatively.
How serious is the interaction between Hydrochlorothiazide-valsartan and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes before anesthesia and correct abnormalities. Monitor neuromuscular function and ECG during and after administration.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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