Drug interactions
Hydrocodone + Levetiracetam
Severity: Minor
Hydrocodone and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam can cause somnolence and dizziness that may add to the sedation of hydrocodone. Clinically significant respiratory depression is uncommon.
What this interaction means in plain words
Hydrocodone and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocodone belongs to Musculoskeletal; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no significant pharmacokinetic interaction is established.
What to do
Monitor for increased drowsiness, especially at initiation or dose increases, and counsel about driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Hydrocodone with Levetiracetam?
MediHelp rates the interaction as minor. Hydrocodone and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levetiracetam can cause somnolence and dizziness that may add to the sedation of hydrocodone. Clinically significant respiratory depression is uncommon.
How serious is the interaction between Hydrocodone and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness, especially at initiation or dose increases, and counsel about driving.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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