Drug interactions
Hydrocodone + Methocarbamol
Severity: Moderate
Hydrocodone and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methocarbamol causes sedation and dizziness, and together with hydrocodone can produce additive CNS and respiratory depression. Impaired alertness and falls are of particular concern in older adults.
What this interaction means in plain words
Hydrocodone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and centrally acting muscle relaxant effects.
What to do
Use the lowest effective doses for the shortest time and monitor for sedation and respiratory depression. Advise against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Methocarbamol
Frequently asked questions
Can I take Hydrocodone with Methocarbamol?
MediHelp rates the interaction as moderate. Hydrocodone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methocarbamol causes sedation and dizziness, and together with hydrocodone can produce additive CNS and respiratory depression. Impaired alertness and falls are of particular concern in older adults.
How serious is the interaction between Hydrocodone and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and monitor for sedation and respiratory depression. Advise against alcohol and driving.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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