Drug interactions
Hydrocodone + Naratriptan
Severity: Moderate
Hydrocodone and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and triptans both act on serotonergic pathways, and combined use has been associated with serotonin syndrome in reports. The risk is probably low but the consequences can be serious.
What this interaction means in plain words
Hydrocodone and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects at the 5-HT1 receptor and possibly through serotonin release or reuptake effects.
What to do
Counsel the patient on signs of serotonin syndrome and monitor, especially at start and with dose increases. Stop one agent if agitation, tremor, hyperthermia or diarrhea develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Hydrocodone with Naratriptan?
MediHelp rates the interaction as moderate. Hydrocodone and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids and triptans both act on serotonergic pathways, and combined use has been associated with serotonin syndrome in reports. The risk is probably low but the consequences can be serious.
How serious is the interaction between Hydrocodone and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on signs of serotonin syndrome and monitor, especially at start and with dose increases. Stop one agent if agitation, tremor, hyperthermia or diarrhea develop.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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