Drug interactions
Hydrocodone + Nicardipine
Severity: Minor
Hydrocodone and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak to moderate CYP3A4 inhibitor and may modestly raise hydrocodone concentrations. The clinical effect is probably small but could increase sedation or respiratory depression in susceptible patients.
What this interaction means in plain words
Hydrocodone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocodone belongs to Musculoskeletal; Nicardipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nicardipine decreases hydrocodone metabolism.
What to do
No routine dose change is needed; watch for increased sedation or slowed breathing when starting nicardipine in a patient on hydrocodone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrocodone and Nicardipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Hydrocodone with Nicardipine?
MediHelp rates the interaction as minor. Hydrocodone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak to moderate CYP3A4 inhibitor and may modestly raise hydrocodone concentrations. The clinical effect is probably small but could increase sedation or respiratory depression in susceptible patients.
How serious is the interaction between Hydrocodone and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for increased sedation or slowed breathing when starting nicardipine in a patient on hydrocodone.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
