Drug interactions
Hydrocodone + Procarbazine
Severity: Major
Hydrocodone and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting activity and can precipitate serotonin syndrome or opioid toxicity when given with opioids. Opioid use is not recommended during MAOI therapy.
What this interaction means in plain words
Hydrocodone and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrocodone belongs to Musculoskeletal; Procarbazine belongs to Oncology.
Why it happens
Weak monoamine oxidase inhibition by procarbazine increases serotonergic activity and may potentiate opioid CNS effects.
What to do
Avoid combining where possible; if opioid analgesia is required, use small test doses with slow titration. Monitor for agitation, hyperthermia, blood pressure changes and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Hydrocodone with Procarbazine?
MediHelp rates the interaction as major. Hydrocodone and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has MAO-inhibiting activity and can precipitate serotonin syndrome or opioid toxicity when given with opioids. Opioid use is not recommended during MAOI therapy.
How serious is the interaction between Hydrocodone and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if opioid analgesia is required, use small test doses with slow titration. Monitor for agitation, hyperthermia, blood pressure changes and respiratory depression.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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