Drug interactions
Hydrocodone + Propafenone
Severity: Moderate
Hydrocodone and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits CYP2D6 and may reduce formation of hydromorphone from hydrocodone, possibly lessening analgesia. Hydrocodone is also metabolized by CYP3A4 to norhydrocodone, so the net clinical impact is uncertain.
What this interaction means in plain words
Hydrocodone and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Propafenone belongs to Cardiovascular.
Why it happens
CYP2D6 inhibition by propafenone alters hydrocodone metabolism.
What to do
Monitor analgesic response and opioid adverse effects, and adjust the hydrocodone dose as needed. Be alert for changes if propafenone is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Hydrocodone with Propafenone?
MediHelp rates the interaction as moderate. Hydrocodone and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits CYP2D6 and may reduce formation of hydromorphone from hydrocodone, possibly lessening analgesia. Hydrocodone is also metabolized by CYP3A4 to norhydrocodone, so the net clinical impact is uncertain.
How serious is the interaction between Hydrocodone and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and opioid adverse effects, and adjust the hydrocodone dose as needed. Be alert for changes if propafenone is started or stopped.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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