Drug interactions
Hydrocodone + Quetiapine
Severity: Moderate
Hydrocodone and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is markedly sedating and can cause orthostatic hypotension, adding to opioid CNS and respiratory depression. Falls and oversedation are the main concerns, especially in older adults.
What this interaction means in plain words
Hydrocodone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from opioid agonism and antihistaminic and alpha-1 blockade by quetiapine.
What to do
Start with lower opioid doses and titrate carefully. Monitor sedation, respiratory rate and orthostatic blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Hydrocodone with Quetiapine?
MediHelp rates the interaction as moderate. Hydrocodone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is markedly sedating and can cause orthostatic hypotension, adding to opioid CNS and respiratory depression. Falls and oversedation are the main concerns, especially in older adults.
How serious is the interaction between Hydrocodone and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower opioid doses and titrate carefully. Monitor sedation, respiratory rate and orthostatic blood pressure.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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