Drug interactions
Hydrocodone + Ramelteon
Severity: Minor
Hydrocodone and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon can cause drowsiness and dizziness, which might add modestly to opioid sedation. No significant respiratory depression is established with ramelteon alone.
What this interaction means in plain words
Hydrocodone and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocodone belongs to Musculoskeletal; Ramelteon belongs to Central Nervous System.
Why it happens
Mild additive sedation; ramelteon acts as a melatonin receptor agonist.
What to do
No routine change is needed; counsel patients about additive drowsiness and monitor for excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Hydrocodone with Ramelteon?
MediHelp rates the interaction as minor. Hydrocodone and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon can cause drowsiness and dizziness, which might add modestly to opioid sedation. No significant respiratory depression is established with ramelteon alone.
How serious is the interaction between Hydrocodone and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel patients about additive drowsiness and monitor for excess sedation.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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