Drug interactions
Hydrocodone + Rifapentine
Severity: Moderate
Hydrocodone and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and can lower hydrocodone exposure, possibly leading to inadequate analgesia. Discontinuing rifapentine may allow hydrocodone levels to rise, risking respiratory depression.
What this interaction means in plain words
Hydrocodone and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4, increasing hydrocodone clearance.
What to do
Monitor analgesic effect and adjust the hydrocodone dose during therapy. After rifapentine is stopped, reduce the opioid dose and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Hydrocodone with Rifapentine?
MediHelp rates the interaction as moderate. Hydrocodone and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and can lower hydrocodone exposure, possibly leading to inadequate analgesia. Discontinuing rifapentine may allow hydrocodone levels to rise, risking respiratory depression.
How serious is the interaction between Hydrocodone and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic effect and adjust the hydrocodone dose during therapy. After rifapentine is stopped, reduce the opioid dose and monitor for sedation and respiratory depression.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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