Drug interactions
Hydrocodone + Sumatriptan
Severity: Moderate
Hydrocodone and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents affect serotonergic transmission, and combined use has been associated with rare serotonin syndrome reports. The overall risk is low but potentially serious.
What this interaction means in plain words
Hydrocodone and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects.
What to do
Advise the patient to report agitation, tremor, sweating, diarrhea or fever and monitor after initiation or dose increases. Stop one agent if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Hydrocodone with Sumatriptan?
MediHelp rates the interaction as moderate. Hydrocodone and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents affect serotonergic transmission, and combined use has been associated with rare serotonin syndrome reports. The overall risk is low but potentially serious.
How serious is the interaction between Hydrocodone and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to report agitation, tremor, sweating, diarrhea or fever and monitor after initiation or dose increases. Stop one agent if serotonin syndrome is suspected.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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