Drug interactions
Hydrocodone + Tranylcypromine
Severity: Major
Hydrocodone and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Use of an opioid with a nonselective MAOI can cause serotonin syndrome or severe opioid toxicity with respiratory depression and coma. Labeling advises against opioid use during and within 14 days of MAOI therapy.
What this interaction means in plain words
Hydrocodone and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrocodone belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Why it happens
Nonselective MAO inhibition increases serotonergic activity and may potentiate opioid CNS depression.
What to do
Avoid hydrocodone during tranylcypromine therapy and for 14 days after stopping it. Use a non-serotonergic alternative analgesic and monitor closely if an opioid cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Hydrocodone with Tranylcypromine?
MediHelp rates the interaction as major. Hydrocodone and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Use of an opioid with a nonselective MAOI can cause serotonin syndrome or severe opioid toxicity with respiratory depression and coma. Labeling advises against opioid use during and within 14 days of MAOI therapy.
How serious is the interaction between Hydrocodone and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hydrocodone during tranylcypromine therapy and for 14 days after stopping it. Use a non-serotonergic alternative analgesic and monitor closely if an opioid cannot be avoided.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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