Drug interactions
Hydrocortisone + Levoketoconazole
Severity: Moderate
Hydrocortisone and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP3A4 and can raise systemic hydrocortisone exposure. Levoketoconazole also lowers cortisol production, so patients may show glucocorticoid excess or adrenal insufficiency depending on the dose and the clinical context.
What this interaction means in plain words
Hydrocortisone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated hydrocortisone metabolism, with possible P-glycoprotein inhibition, plus separate inhibition of adrenal steroidogenesis.
What to do
Monitor for signs of cortisol excess or deficiency and adjust the hydrocortisone dose to clinical response. Check serum or urinary cortisol as appropriate during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Hydrocortisone with Levoketoconazole?
MediHelp rates the interaction as moderate. Hydrocortisone and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP3A4 and can raise systemic hydrocortisone exposure. Levoketoconazole also lowers cortisol production, so patients may show glucocorticoid excess or adrenal insufficiency depending on the dose and the clinical context.
How serious is the interaction between Hydrocortisone and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of cortisol excess or deficiency and adjust the hydrocortisone dose to clinical response. Check serum or urinary cortisol as appropriate during treatment.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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