Drug interactions
Hydrocortisone + Linagliptin
Severity: Moderate
Hydrocortisone and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is a weak CYP3A4 inducer and could slightly lower linagliptin exposure, but the legacy direction is doubtful. The more relevant effect is that corticosteroids raise blood glucose and oppose the glucose-lowering effect of linagliptin.
What this interaction means in plain words
Hydrocortisone and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through corticosteroid-induced hyperglycemia, with possible minor CYP3A4 induction.
What to do
Monitor blood glucose and HbA1c and adjust antidiabetic therapy when systemic hydrocortisone is started, changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Hydrocortisone with Linagliptin?
MediHelp rates the interaction as moderate. Hydrocortisone and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone is a weak CYP3A4 inducer and could slightly lower linagliptin exposure, but the legacy direction is doubtful. The more relevant effect is that corticosteroids raise blood glucose and oppose the glucose-lowering effect of linagliptin.
How serious is the interaction between Hydrocortisone and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and adjust antidiabetic therapy when systemic hydrocortisone is started, changed or stopped.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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